Tiny antibody fragments raised in camels find drug targets in human breast...
A new discovery published online in The FASEB Journal promises to help physicians identify patients most likely to benefit from breast cancer drug therapies. If the compound, called "Nanobody," proves...
View ArticleNew structure of an important immune system complex resolves a 10-year...
(Medical Xpress) -- Researchers at the University of Toronto and the University of Bath have resolved a longstanding controversy surrounding an important structure of the immune system that could...
View ArticleBreast cancer drug pushes colon cancer cells to their death
A new treatment for colon cancer that combines a chemotherapy agent approved to treat breast cancer and a cancer-fighting antibody is ready for clinical trials, according to Penn State College of...
View ArticleMajor advance in the treatment of Hendra virus reported
A collaborative research team from Boston University School of Medicine (BUSM), the Uniformed Services University of the Health Sciences (USU), the University of Texas Medical Branch (UTMB) and...
View ArticleCombination therapy shows potent tumor growth inhibition in preclinical studies
Combining the investigational agents REGN910 and aflibercept yielded statistically significant improvements in antitumor effects in animal models compared with either agent alone, according to results...
View ArticleA new way to stimulate the immune system and fight infection
A study carried out by Eric Vivier and Sophie Ugolini at the Marseille-Luminy Centre for Immunology has just reveal a gene in mice which, when mutated, can stimulate the immune system to help fight...
View ArticleBright future ahead for antibody cancer therapy
Antibodies, once touted as the "magic bullets" of cancer care, are now fulfilling that promise and more advances are on the way, say cancer researchers at the Georgetown Lombardi Comprehensive Cancer...
View ArticleRare immune cells could hold key to treating immune disorders
The characterisation of a rare immune cell's involvement in antibody production and ability to 'remember' infectious agents could help to improve vaccination and lead to new treatments for immune...
View ArticleResearchers find potential key to new treatment for mantle cell lymphoma
Researchers at Moffitt Cancer Center and colleagues have demonstrated that the inhibition of signal transducer and activator of transcription 3 (STAT3) in mouse models of mantle cell lymphoma (MCL), an...
View ArticleMonoclonal antibody effective therapy for diabetic retinopathy
(HealthDay)—An antibody can reduce retinal vascular leakage and inflammation in rat models of diabetic retinopathy, according to a study published online Oct. 1 in Diabetes.
View ArticleAnti-cancer drug fights immune reaction in some infants with Pompe disease
Adding a third anti-cancer agent to a current drug cocktail appears to have contributed to dramatic improvement in three infants with the most severe form of Pompe disease—a rare, often-fatal genetic...
View ArticleScientists block stomach tumor growth
(Medical Xpress)—Monash Institute of Medical Research scientists may have discovered a way of blocking stomach tumours from growing and spreading, according to a paper published in the...
View ArticleNew monoclonal antibody inhibits tumor growth in advanced solid tumors in...
A newly developed antibody targeting a signalling pathway that is frequently active in solid tumours has shown encouraging signs of efficacy in its first trial in humans, researchers will report at the...
View ArticlePotent antibodies neutralize HIV and could offer new therapy, study finds
(Medical Xpress)—Having HIV/AIDS is no longer a death sentence, but it's still a lifelong illness that requires an expensive daily cocktail of drugs—and it means tolerating those drugs' side effects...
View ArticleNew targeted therapy for advanced prostate cancer shows anti-tumor activity...
Few available treatment options exist once prostate cancer has spread to other parts of the body and has failed to respond to therapies that involve blocking the male hormone androgen. Patients with...
View ArticleAlzheimer's disease in mice alleviated promising therapeutic approach for humans
Pathological changes typical of Alzheimer's disease were significantly reduced in mice by blockade of an immune system transmitter. A research team from Charité - Universitätsmedizin Berlin and the...
View ArticleStudy shows antibody therapy clears Alzheimer's plaques in mice
Antibodies against amyloid beta (Aβ) protein deposits that are thought to play a role in Alzheimer's disease have shown some success in preventing the buildup of deposits in animals, but they have not...
View ArticleWeekly dose reduces targeted drug's side effects, but not its activity...
A potent chemotherapy agent wrapped within a monoclonal antibody selectively destroys the malignant cells responsible for acute lymphocytic leukemia (ALL) in either weekly or monthly dosing,...
View ArticlePeptides for the treatment of severe diseases
A new class of drugs for the treatment of severe diseases such as cancer and autoimmune diseases is developed by the start-up Bicycle Therapeutics. The company is generating bicyclic peptides that can...
View ArticleNovel monoclonal antibody inhibits tumor growth in breast cancer and...
A monoclonal antibody targeting a protein known as SFPR2 has been shown by researchers at the University of North Carolina to inhibit tumor growth in pre-clinical models of breast cancer and angiosarcoma.
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